Karanian, J. W., Chiesa, O. A., Desai, P., Seward, K. P., Kreitz, M., Virmani,
R., & Pritchard, W. F. (n.d.). Drug Retention in the Coronary and Femoral
Arteries is Dependent on the Route of Administration in Swine: Assessment
of Intimal and Adventitial Intro-Vascular and Systemic Pharmacokinetics and
Toxicology with Nanopartical Albumin Bound-Paclitaxel.
This study reported the results of a experiment studying the effects of
varying coronary delivery on nanoparticle retention, highlighting its
effectiveness in adventitial delivery versus luminal and intimal
pathways. This study then continued to suggest the application of the
latter in determining the efficiency of delivering anti-restenotic drugs
and the resulting pharmokinetic and toxicity profiles.