Wu, Y.-J., Sala-Newby, G. B., Shu, K.-T., Yeh, H.-I., Nakayama, K. I., Nakayama,
K., . . . Bond, M. (n.d.). S-phase Kinase-associated protein-2 (Skp2)
promotes vascular smooth muscle cell proliferation and neointima formation
in vivo.
This study investigated the role of the S-phase Kinease-associated
protein-2 (SKP2) in tissue proliferation, a leading cause of in-stent
restinosis, venous graft failure, and atherosclerosis. Further
researching Vascular smooth muscle cell proliferation (VSMC) and its
reliance on the Skp2 protein, this study investigated its effect on VSMC
and neointimal formation. Concluding that the reduction of SKp2 protein
in mice results in a significantly reduced neointimal growth area, this
study evaluated said protein manipulation and aimed to identify
additional factors in tissue proliferation control.